Here are some hotels and motels to get you started. You can find more at www.hotels.com and www.motels.com. If it's camping at Alafia River State Park that you have in mind, go to Reserve America to check on availability.

Sun City Center - Comfort Inn - Southwest about 18 miles just off I-75
Sun City Center Comfort Inn

Brandon - Baymont Inns & Suites - Northwest about 18 miles - off I-75
Baymont Inns & Suites - Brandon

Brandon - La Quinta Inn - Northwest about 18 miles - off I-75
La Quinta Inn & Suites Brandon

Plant City - Comfort Inn - about 23 miles Northeast off I-4
Comfort Inn - Plant City

Ruskin - Mariner's Club - Bahia Beach - Southwest on the water about 27 miles
Mariner's Club Bahia Beach Resort

Ellenton - 34 miles Southwest just off I-75
Hampton Inn Ellenton